Hypolipidemic Effect of Hemp Seed Oil from the Northern Morocco Endemic Beldiya Ecotype in a Mice Model: Comparison with Fenofibrate Hypolipidemic Drugs

Introduction. Cannabis sativa is a source of oil seeds for pharmaceutical, cosmetic, and food uses. Objective. The aim this study to evaluate the hypolipidemic effect hemp seed (HSO) obtained from local ecotype called “Beldiya.” Methods. extraction HSO was carried out by cold press method. Then, fatty acid tocopherol composition analyzed, respectively, GC-FID HPLC. activity at dose 3.5 7 mg/kg body weight evaluated in Triton WR-1339-induced hyperlipidemic mice measuring plasma cholesterol (total lipid, HDL, LDL), triglycerides, atherogenic index using enzymatic methods. Fenofibrate used as standard drug weight. Results. Analyzed shows high unsaturated acids’ content with dominance linoleic (48.85%), oleic (21.82%), well α- γ-linolenic (14.72%). result demonstrates that typical vegetable contains concentration γ-tocopherol (456 mg·kg−1 oil). Furthermore, administration decreases total cholesterol, LDL-cholesterol while increases HDL-cholesterol. Consequently, reduces LDL/HDL ratio. fenofibrate relatively more marked comparatively especially concerning its LDL fraction. Conclusions. has an interesting on lipid parameters might be beneficial treatment hyperlipidemia prevention atherosclerosis.